Follow-up study on a susceptibility locus for schizophrenia on chromosome 6q
نویسندگان
چکیده
منابع مشابه
Follow-up study on a susceptibility locus for schizophrenia on chromosome 6q.
Evidence for suggestive linkage to schizophrenia with chromosome 6q markers was previously reported from a two-stage approach. Using nonparametric affected sib pairs (ASP) methods, nominal p-values of 0.00018 and 0.00095 were obtained in the screening (81 ASPs; 63 independent) and the replication (109 ASPs; 87 independent) data sets, respectively. Here, we report a follow-up study of this 50cM ...
متن کاملSuggestive evidence for a schizophrenia susceptibility locus on chromosome 6q and a confirmation in an independent series of pedigrees.
We have investigated whether there is a locus on chromosome 6 that confers an increased susceptibility to schizophrenia using a two-stage approach and nonparametric linkage analysis. Allele sharing identical by descent (IBD) and multipoint maximum likelihood score (MLS) statistics were employed. Results from two tested data sets, a first data set, or genome scanning data set, and a second repli...
متن کاملLung Cancer Risk among Light and Never Smokers A Susceptibility Locus on Chromosome 6q Greatly Increases
Authors' A M.D. Ander Cincinnat Minnesota Detroit, M 6University 7National C Universi ty 9Washingto Institute, G Ohio; and Maryland Note: Supp Research O Correspon ogy, Unive Street, Uni 792-0807;
متن کاملA susceptibility locus on chromosome 6q greatly increases lung cancer risk among light and never smokers.
Cigarette smoking is the major cause for lung cancer, but genetic factors also affect susceptibility. We studied families that included multiple relatives affected by lung cancer. Results from linkage analysis showed strong evidence that a region of chromosome 6q affects lung cancer risk. To characterize the effects that this region of chromosome 6q region has on lung cancer risk, we identified...
متن کاملA strabismus susceptibility locus on chromosome 7p.
Strabismus has been known to have a significant genetic component, but the mode of inheritance and the identity of the relevant genes have been enigmatic. This paper reports linkage analysis of nonsyndromic strabismus. The principal results of this study are: (i) the demonstrated feasibility of identifying and recruiting large families in which multiple members have (or had) strabismus; (ii) th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Medical Genetics
سال: 1999
ISSN: 0148-7299,1096-8628
DOI: 10.1002/(sici)1096-8628(19990820)88:4<337::aid-ajmg9>3.0.co;2-a